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PHYSICAL TRANSFORMATION PLANT

TIS NUTRA
High-efficiency ingredients

tis nutra logo

PHYSICAL TRANSFORMATION PLANT

Compaction and Granulation of actives in Hipering Technology

tis nutra logo

PHYSICAL TRANSFORMATION PLANT

High quality standards

tis nutra logo

Industrial Solutions

Adaptation of raw materials

according to the needs of the manufacturer of nutritional supplements

About

TIS NUTRA has industrial facilities that comply with GMP regulations for the adaptation of raw materials based on the industrial needs of the manufacturer of food supplements and nutraceuticals.

We control the batches of raw materials according to the needs of each client, optimizing the nutraceutical both at the level of the manufacturer of the active ingredient and the manufacturer of the final dosage form.

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Procesos

NUTRACEUTICALS

TIS NUTRA adapted nutraceutical actives according to the characteristics of each production process, without using any solvent, excipient or any other chemical product.

We carry out physical transformation processes of actives obtaining an improvement in critical parameters such as fluidity, density, particle size, homogeneity, solubility, volatility and hygroscopicity of the raw material. Hipering® technology allows or the optimization of the active ingredient according to the manufacture of the final product..

fabricación

PATENTED TECHNOLOGY

Continuous improvement and adaptation of raw materials to each industrial process has resulted in three patents at European level:

  • EP3705475A1: HIGH-DENSITY L-TRYPTOPHAN, ITS PREPARATION AND USES THEREOF
  • EP3705117A1: MELATONIN HAVING IMPROVED WATER SOLUBILITY, ITS PREPARATION AND USES THEREOF
  • 118925PEP: PROCESS FOR PREPARING COMPACTED COENZYME Q10 PARTICLES OF HIGH DENSITY AND IMPROVED FLOWABILITY (Request made)
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Slide 01
1

Initial shape (S)
ρ = 0,15 g/ml
Capsule size: 22 oblong

Slide 02
2

Ribbon (R)



Slide 03
3

Final shape (F)
ρ = 0,65 g/ml
Capsule size: 10 oval

BENEFITS OF HIPERING® TECHNOLOGY

HIPERING® TECHNOLOGY INDUSTRIAL BENEFIT
  • Reduction of adhesion of raw materials to equipment walls.
  • Higher flow rate.
  • It reduces the volatility of APIs.
  • Lower percentage of losses.
  • Higher performance and process speed.
  • Shorter cleaning times.
Density modification.
  • APIs suitable for obtaining lower volume final dosage forms.
  • Reduces the amount of packaging material and storage space required.
  • Less use of excipients.
Control of hardness, porosity and geometry of the particles.
  • Optimal disintegration/dissolution of tablets and capsules.
  • Improved friability/hardness in tablets.
  • Galenically facilitates obtaining delayed/prolonged release forms.
Obtaining a homogeneous PSD. Obtaining homogeneous mixtures.
Solvents do not need to be added.
  • Maintenance of intact chemical/purity properties.
  • Avoids water-induced degradation products.
  • Does not require an ATEX equipment / fabrication room.
Standardization of the physical specifications of raw materials (mainly amino acids and natural extracts)
  • Possibility of obtaining batches with the least possible variability.
  • Facilita la fabricación en continuo.
  • Facilitates continuous manufacturing.
Density increase
  • Final unit doses with lower volume with the possibility of adding a greater number of components offering a greater benefit for the consumer.
  • Less use of excipients.
  • Reduction of packaging material and storage volume.
fabricación

Industrial Benefits

  • Increased productivity and performance Our technology allows the physical modification of the raw material, keeping its purity and chemical specifications intact. This allows for the reduced use of excipients, a reduction in gelatin consumption, a reduction in packaging material and the costs associated with them.
  • High-density custom APIs Improving the physical properties of actives without modifying purity or chemical properties is not an easy process. At TIS, we have developed a patented technology capable of customizing each active ingredient, without the need to include any type of solvent, excipient or other chemical product.
  • Better stability and uniformity of content Our know-how allows us to optimize the manufacturing process to obtain batches with the least possible variability. We facilitate the continuous manufacture of homogeneous mixtures (homogeneous PSD).
  • Final forms of a smaller volume We increase the density of the nutraceutical active ingredients without the need to add excipients, adapting them for the manufacture of smaller volume galenic forms allowing us to include the necessary dose in a single tablet/capsule per dose.
Procesos

Benefits for the consumer

  • Smaller galenic forms with the same effectiveness
  • Same dosage in fewer capsule /tablets
  • Avoids swallowing issues
  • Greater adherence to treatment
Productos Desarrollados
  • Aspartic Acid GR
  • Boswellia Serrata GR
  • Chondroitin Sulphate GR
  • Cistus GR
  • Coenzyme Q10 GR
  • Collagen HD
  • Eggshell Membrane GR
  • Flower Pollen Extract HD
  • Frangula & Ascophyllum GR
  • Grape Seed GR
  • Iron Pyrophosphate HD
  • L- Cystine HD
  • L- Theanine HD
  • L- Theanine GR
  • L- Tryptophan HD
  • L- Tyrosine HD
  • Melatonin GR
  • Methylsulfonylmethane GR
  • Quercetin GR
  • Resveratrol GR
  • Serenoa Repens GR
  • Taurine GR