Technology

Miniaturization Pharmaceutical Technology®

TIS provides a pharmaceutical service for the physical transformatiion of the raw materials translated into a 50-60% increase in the operational efficiency for the manufacturers of finished dosage forms and a dramatic impact in the reduction of the industrial costs.

TIS do have an exclusive and proprietary Miniaturization Pharmaceutical Technology and TIS holds patent granted processes, for the reduction of the size of the finished dosage forms.

We have an exclusive and  propietary Miniaturization Pharmaceutical Technology

Hipering for miniaturization

Particle rearrangement occurs initially as powder particles begin filling void spaces. Particle shape and size are key actors in the rearrangement process.

Particle deformation increases the points of contact between particles where bondingoccurs and is described as plastic deformation Particle fragmentation fracturing createsmultiple new surface sites, additional contact points, and potential bonding sites.

Particle bonding occurs when plastic deformation and fragmentation occur.

PATENTS:

  • Melatonin having improved water solubility, EP19382161.8.
  • High-density L-tryptophan, EP19382163.4.

Increase your operational effectiveness by 70%

Cost reduction: less use of excipients, diminish the gelatin consumption reduction of the size of the package and reduction of logistic costs.
Product suitable for direct compression.
Development of new slow release dosage forms

Less size more benefits

From industrial benefits to consumer benefits

INDUSTRIAL BENEFITS

REDUCING YOUR INDUSTRIAL OPERATIONAL COSTS

BENEFIT 1

Increase the productivity and yield (pills/hour)

BENEFIT 2

Reduce operational costs

BENEFIT 3

Reduce the packaging size

CONSUMER BENEFITS

BENEFIT 1

Less size, same purity, health benefit

BENEFIT 2

Reduce the number of pills per day

BENEFIT 3

Faster to swallow

BENEFIT 4

Access to new market segment

ENVIRONMENTAL BENEFITS

BENEFIT 1

Lack of solvents, reagents, excipients and chemicals

BENEFIT 2

Environmental friendly

Immediate dossier incorporation

Physical transformation of API with identical purity, identical chemical properties and identical HPLC profile compared to the original API and keeping the stability of the API.

TIS manufacturing is an impurity free process.

Our process guaranties the same properties than original APIs